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1

Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation

Alépée, N., Bessou-Touya, S., Cotovio, J., de Smedt, A., de Wever, B., Faller, C., Jones, P., Le Varlet, B., Marrec-Fairley, M., Pfannenbecker, U., Tailhardat, M., van Goethem, F., McNamee, P.

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

2

Validation des méthodes pour la recherche d’ADN HPV oncogènes au sein d’une structure d’ACP dans la perspective d’une accréditation

Bloget, F., Declerck, D., Debaque, H., Alepee, B., Battin-Bertho, R., Boivin, J.-F., Ciupea, A., Courtin, P., Dejardin, L., Demol, B.

Journal:

Annales de Pathologie

Year:

2011

Language:

french

File:

PDF, 64 KB

french, 2011

3

Expérience de la mise en place d’une plateforme automatisée pour la recherche d’ADN HPV oncogènes

Bloget, F., Declerck, D., Debaque, H., Alepee, B., Battin-Bertho, R., Ciupea, A., Courtin, P., Dejardin, L., Demol, B., Doumecq-Lacoste, J.-M., Duclos, J., Henninger, J.-F., Kafe, H., Loridon, B., Mar

Journal:

Annales de Pathologie

Year:

2012

Language:

french

File:

PDF, 60 KB

french, 2012

4

The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization

Piroird, Cécile, Ovigne, Jean-Marc, Rousset, Françoise, Martinozzi-Teissier, Silvia, Gomes, Charles, Cotovio, José, Alépée, Nathalie

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

5

Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD)

Barroso, João, Pfannenbecker, Uwe, Adriaens, Els, Alépée, Nathalie, Cluzel, Magalie, De Smedt, Ann, Hibatallah, Jalila, Klaric, Martina, Mewes, Karsten R., Millet, Marion, Templier, Marie, McNamee, Pa

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 831 KB

english, 2017

6

Integrated pre-concentrator gas sensor microsystem for ppb level benzene detection

Leidinger, Martin, Rieger, Max, Sauerwald, Tilman, Alépée, Christine, Schütze, Andreas

Journal:

Sensors and Actuators B: Chemical

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

7

CON4EI: SkinEthic™ Human Corneal Epithelium Eye Irritation Test (SkinEthic™ HCE EIT) for hazard identification and labelling of eye irritating chemicals

Van Rompay, A.R., Alépée, N., Nardelli, L., Hollanders, K., Leblanc, V., Drzewiecka, A., Gruszka, K., Guest, R., Kandarova, H., Willoughby, J.A., Verstraelen, S., Adriaens, E.

Journal:

Toxicology in Vitro

Year:

2017

Language:

english

File:

PDF, 1.42 MB

english, 2017

8

Reprint of “CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals”

Adriaens, E., Alépée, N., Kandarova, H., Drzewieckac, A., Gruszka, K., Guest, R., Willoughby, J.A., Verstraelen, S., Van Rompay, A.R.

Journal:

Toxicology in Vitro

Year:

2018

Language:

english

File:

PDF, 211 KB

english, 2018

9

Reprint of “CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals”

Verstraelen, Sandra, Maglennon, Gareth, Hollanders, Karen, Boonen, Francis, Adriaens, Els, Alépée, Nathalie, Drzewiecka, Agnieszka, Gruszka, Katarzyna, Kandarova, Helena, Willoughby, Jamin A., Guest,

Journal:

Toxicology in Vitro

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

10

Computational chemistry, systems biology and toxicology. Harnessing the chemistry of life: revolutionizing toxicology. A commentary

Ian Kimber, Colin Humphris, Carl Westmoreland, Nathalie Alepee, Gianni Dal Negro, Irene Manou

Journal:

Journal of Applied Toxicology

Year:

2011

Language:

english

File:

PDF, 83 KB

english, 2011

11

3D measurements of the knee prosthesis surfaces applied in optimizing of manufacturing process

I. Hilerio, T. Mathia, C. Alepee

Journal:

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

12

Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

Carsten Goebel, Pierre Aeby, Nadège Ade, Nathalie Alépée, Aynur Aptula, Daisuke Araki, Eric Dufour, Nicola Gilmour, Jalila Hibatallah, Detlef Keller, Petra Kern, Annette Kirst, Monique Marrec-Fairley,

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 627 KB

english, 2012

13

The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing – The report of an ECVAM–EFPIA workshop

Mara Ceridono, Pär Tellner, Daniel Bauer, João Barroso, Nathalie Alépée, Raffaella Corvi, Ann De Smedt, Mick D. Fellows, Neil K. Gibbs, Eckhard Heisler, Abigail Jacobs, Dagmar Jirova, David Jones, Hel

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

14

Complexes triamminés du rhodium(III) II. Préparation de la rhodium(III)-trichloro-triammine à partir de la rhodium(III)-trihydroxo-triammine étude de son spectre infrarouge et de sa dégradation thermique dans diverses atmosphères

G. Pannetier, R. Bonnaire, P. Alepee, P. Davous, V. Huynh

Journal:

Journal of the Less Common Metals

Year:

1969

File:

PDF, 670 KB

1969

15

Complexes triamminés du rhodium(III) I. Un nouveau complexe du rhodium(III): La rhodium(III)-trihydroxo-triammine préparation, identification et étude de quelques unes de ses propriétés physico-chimiques

G Pannetier, R Bonnaire, P Alepee, P Davous, V Huynh

Journal:

Journal of the Less Common Metals

Year:

1969

File:

PDF, 930 KB

1969

16

Complexes de l'iridium avec le cyclooctadiène-1,5 1. Propriétés physicochimiques de [(COD-1,5)IrCl]2 variété orange et de [(COD-1,5)IrHCl2]2

G. Pannetier, R. Bonnaire, P. Fougeroux, P. Alépée

Journal:

Journal of the Less Common Metals

Year:

1970

File:

PDF, 794 KB

1970

17

Complexes monoamminés du rhodium(III). Un nouveau complexe monoamminé du rhodium(III): La rhodium(III)-trihydroxo-diaquo-monoammine

G. Pannetier, R. Bonnaire, P. Alépée, P. Davous, V. Huynh

Journal:

Journal of the Less Common Metals

Year:

1970

File:

PDF, 264 KB

1970

18

Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals

F. Van Goethem, E. Adriaens, N. Alépée, F. Straube, B. De Wever, M. Cappadoro, S. Catoire, E. Hansen, A. Wolf, P. Vanparys

Journal:

Toxicology in Vitro

Year:

2006

Language:

english

File:

PDF, 391 KB

english, 2006

19

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

Laurie Scott, Chantra Eskes, Sebastian Hoffmann, Els Adriaens, Nathalie Alepée, Monica Bufo, Richard Clothier, Davide Facchini, Claudine Faller, Robert Guest, John Harbell, Thomas Hartung, Hennicke Ka

Journal:

Toxicology in Vitro

Year:

2010

Language:

english

File:

PDF, 383 KB

english, 2010

20

Assessment of the optimized SkinEthic™ Reconstructed Human Epidermis (RHE) 42 bis skin irritation protocol over 39 test substances

Carine Tornier, Carole Amsellem, Anne de Brugerolle de Fraissinette, Nathalie Alépée

Journal:

Toxicology in Vitro

Year:

2010

Language:

english

File:

PDF, 411 KB

english, 2010

21

A catch-up validation study on reconstructed human epidermis (SkinEthic™ RHE) for full replacement of the Draize skin irritation test

Nathalie Alépée, Carine Tornier, Cécile Robert, Carole Amsellem, Marie-Hélène Roux, Olivier Doucet, Jean Pachot, Marisa Méloni, Anne de Brugerolle de Fraissinette

Journal:

Toxicology in Vitro

Year:

2010

Language:

english

File:

PDF, 810 KB

english, 2010

22

Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors

K. Schroeder, K.D. Bremm, N. Alépée, J.G.M. Bessems, B. Blaauboer, S.N. Boehn, C. Burek, S. Coecke, L. Gombau, N.J. Hewitt, J. Heylings, J. Huwyler, M. Jaeger, M. Jagelavicius, N. Jarrett, H. Ketelsle

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 506 KB

english, 2011

23

Update of the COLIPA eye irritation task force strategy and programme for development of in vitro methods

B. Le Varlet, N. Alepee, S. Bessou-Touya, A. De Smedt, B. De Wever, J. Harbell, P. Jones, P. Mcnamee, M. Marrec-Fairley, U. Pfannenbecker, M. Tailhardat, F. Van Goethem

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 90 KB

english, 2010

24

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation

Pfannenbecker, U., Bessou-Touya, S., Faller, C., Harbell, J., Jacob, T., Raabe, H., Tailhardat, M., Alépée, N., De Smedt, A., De Wever, B., Jones, P., Kaluzhny, Y., Le Varlet, B., McNamee, P., Marrec-

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

25

In vitro acute skin irritancy of 184 cosmetic ingredients using the validated EPISKIN model protocol

José Cotovio, Marie-Hélène Grandidier, Damien Lelievre, Nathalie Alepee, Roland Roguet, Estelle Tinois-Tessonneaud, Jacques Leclaire

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 110 KB

english, 2008

26

Sub-categorisation of skin corrosive chemicals by the EpiSkin™ reconstructed human epidermis skin corrosion test method according to UN GHS: Revision of OECD Test Guideline 431

Alépée, N., Grandidier, M.H., Cotovio, J.

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 364 KB

english, 2014

27

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

Adriaens, Els, Barroso, João, Eskes, Chantra, Hoffmann, Sebastian, McNamee, Pauline, Alépée, Nathalie, Bessou-Touya, Sandrine, Smedt, Ann, Wever, Bart, Pfannenbecker, Uwe, Tailhardat, Magalie, Zuang,

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

28

Targeted treatment of hepatitis B virus (HBV) infection by Asialo-interferon beta and assessment of its effect using HBV nude mice model established by in vivo transfection. Gastrointestinal Unit and *Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA

Adriaens, Els, Barroso, João, Eskes, Chantra, Hoffmann, Sebastian, McNamee, Pauline, Nathalie, Alépée, Bessou-Touya, Sandrine, De Smedt, Ann, de Wever, Bart, Pfannenbecker, Uwe, Tailhardat, Magalie, K

Journal:

Year:

1995

Language:

english

File:

PDF, 160 KB

english, 1995

29

Draize test for eye irritation: Importance of the endpoints evaluated with regard to UN GHS/EU CLP classification

Adriaens, Els, Barroso, João, Eskes, Chantra, Hoffmann, Sebastian, McNamee, Pauline, Nathalie, Alépée, Bessou-Touya, Sandrine, De Smedt, Ann, de Wever, Bart, Pfannenbecker, Uwe, Tailhardat, Magalie, K

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 74 KB

english, 2013

30

Skin sensitisation – Moving forward with non-animal testing strategies for regulatory purposes in the EU

Basketter, David, Alépée, Nathalie, Casati, Silvia, Crozier, Jonathan, Eigler, Dorothea, Griem, Peter, Hubesch, Bruno, de Knecht, Joop, Landsiedel, Robert, Louekari, Kimmo, Manou, Irene, Maxwell, Gavi

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 446 KB

english, 2013

31

The usefulness of the validated SkinEthic™ RHE test method to identify skin corrosive UN GHS subcategories

Alépée, Nathalie, Robert, Clément, Tornier, Carine, Cotovio, José

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 339 KB

english, 2014

32

The importance of understanding drivers of irritation in vivo for selection of chemicals used in the development and evaluation of in vitro eye irritation assays: Cosmetics Europe analysis

Barroso, J., Alépée, N., De Smedt, A., De Wever, B., Hibatallah, J., McNamee, P., Mewes, K., Millet, M., Pfannenbecker, U., Tailhardat, M., Templier, M.

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

33

Reprint of: Characterising hepatic mitochondrial function as a model for systemic toxicity: A commentary

Leach, Andrew R., Wallace, Kendall, Alepee, Nathalie, Daston, George, Humphris, Colin, Manou, Irene, Modi, Sandeep, Ringeissen, Stephanie, Whelan, Maurice, Kimber, Ian

Journal:

Year:

2012

Language:

english

File:

PDF, 272 KB

english, 2012

34

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

Reisinger, Kerstin, Hoffmann, Sebastian, Alépée, Nathalie, Ashikaga, Takao, Barroso, Joao, Elcombe, Cliff, Gellatly, Nicola, Galbiati, Valentina, Gibbs, Susan, Groux, Hervé, Hibatallah, Jalila, Keller

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

35

Use of HPLC/UPLC-spectrophotometry for detection of formazan in in vitro Reconstructed human Tissue (RhT)-based test methods employing the MTT-reduction assay to expand their applicability to strongly coloured test chemicals

Alépée, N., Barroso, J., De Smedt, A., De Wever, B., Hibatallah, J., Klaric, M., Mewes, K.R., Millet, M., Pfannenbecker, U., Tailhardat, M., Templier, M., McNamee, P.

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

36

Categorization of Chemicals According to Their Relative Human Skin Sensitizing Potency

Basketter, David A., Alépée, Nathalie, Ashikaga, Takao, Barroso, João, Gilmour, Nicola, Goebel, Carsten, Hibatallah, Jalila, Hoffmann, Sebastian, Kern, Petra, Martinozzi-Teissier, Silvia, Maxwell, Gav

Journal:

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

37

Microsystem for High-Temperature Gas Phase Reactions

Alepee, C., Vulpescu, L., Cousseau, P., Renaud, P., Maurer, R., Renken, A.

Journal:

Measurement and Control

Year:

2000

Language:

english

File:

PDF, 3.12 MB

english, 2000

38

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Alépée, Natalie

Journal:

Year:

2014

Language:

english

File:

PDF, 4.89 MB

english, 2014

39

An integrated testing strategy for in vitro skin corrosion and irritation assessment using SkinEthic™ Reconstructed Human Epidermis

Alépée, Nathalie, Grandidier, Marie-Hélène, Tornier, Carine, Cotovio, José

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

40

Pulsed Laser Deposition of Metal Oxide Nanoparticles, Agglomerates, and Nanotrees for Chemical Sensors

Huotari, Joni, Lappalainen, Jyrki, Puustinen, Jarkko, Baur, Tobias, Alépée, Christine, Haapalainen, Tomi, Komulainen, Samuli, Pylvänäinen, Juho, Spetz, Anita Lloyd

Journal:

Procedia Engineering

Year:

2015

Language:

english

File:

PDF, 985 KB

english, 2015

41

Multi-laboratory validation of SkinEthic HCE test method for testing serious eye damage/eye irritation using liquid chemicals

Alépée, N., Leblanc, V., Adriaens, E., Grandidier, M.H., Lelièvre, D., Meloni, M., Nardelli, L., Roper, C.S., Santirocco, E., Toner, F., Van Rompay, A., Vinall, J., Cotovio, J.

Journal:

Toxicology in Vitro

Year:

2016

Language:

english

File:

PDF, 806 KB

english, 2016

42

Prospective multicentre study of the U-SENS test method for skin sensitization testing

Alépée, N., Piroird, C., Aujoulat, M., Dreyfuss, S., Hoffmann, S., Hohenstein, A., Meloni, M., Nardelli, L., Gerbeix, C., Cotovio, J.

Journal:

Toxicology in Vitro

Year:

2015

Language:

english

File:

PDF, 615 KB

english, 2015

43

Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkin™ using HPLC/UPLC-spectrophotometry in the MTT-reduction assay

Alépée, N., Hibatallah, J., Klaric, M., Mewes, K.R., Pfannenbecker, U., McNamee, P.

Journal:

Toxicology in Vitro

Year:

2016

Language:

english

File:

PDF, 516 KB

english, 2016

44

[IEEE 2015 IEEE SENSORS - Busan, South Korea (2015.11.1-2015.11.4)] 2015 IEEE SENSORS - A novel low-cost pre-concentrator concept to boost sensitivity and selectivity of gas sensor systems

Schutze, Andreas, Leidinger, Martin, Schmitt, Bastian, Sauerwald, Tilman, Rieger, Max, Alepee, Christine

Year:

2015

Language:

english

File:

PDF, 878 KB

english, 2015

45

Multi-laboratory evaluation of SkinEthic HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemical testing

Alépée, N., Adriaens, E., Grandidier, M.H., Meloni, M., Nardelli, L., Vinall, C.J., Toner, F., Roper, C.S., Van Rompay, A.R., Leblanc, V., Cotovio, J.

Journal:

Toxicology in Vitro

Year:

2016

Language:

english

File:

PDF, 866 KB

english, 2016

46

EURL ECVAM – Cosmetics Europe prospective validation study of reconstructed human tissue-based test methods for serious eye damage/eye irritation testing

Barroso, J., Alépée, N., Cole, T., Eskes, C., Freeman, S.J., Liška, R., McNamee, P., Pfannenbecker, U., Reus, A.A., Rubingh, C.M., Schaeffer, M.W., Zuang, V.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 69 KB

english, 2015

47

Serious eye damage/eye irritation assessment: How SkinEthic™ HCE reconstructed human corneal test method can address this area for liquid test substances

Leblanc, V., Adriaens, E., Grandidier, M.-H., Hollanders, K., Jacobs, A., Meloni, M., Nardelli, L., Roper, C., Santirocco, E., Toner, F., Van Rompay, A., Vinall, J.L., Cotovio, J., Alepee, N.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 69 KB

english, 2015

48

The importance of understanding drivers of classification in vivo for selection of chemicals used in the development and evaluation of in vitro serious eye damage/eye irritation assays: Cosmetics Europe analysis

Barroso, J., Alépée, N., Adriaens, E., Cluzel, M., De Smedt, A., Hibatallah, J., Klaric, M., Mewes, K.R., Millet, M., Pfannenbecker, U., Templier, M., McNamee, P.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 88 KB

english, 2015

49

Toward the validation of U-SENS™ skin sensitization method: Multicentric studies outcomes

Alepee, N., Piroird, C., Aujoulat, M., Dreyfuss, S., Hoffmann, S., Hohenstein, A., Meloni, M., Nardelli, L., Pearson, N., Cotovio, J., Leblanc, V.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 68 KB

english, 2015

50

The Activation of Dendritic Cell Event in the Adverse Outcome Pathway for Skin Sensitization addressed by U-SENS™

Piroird, C., Ovigne, J.M., Rousset, F., Teissier, S. Martinozzi, Gomes, C., Cotovio, J., Alepee, N., Leblanc, V.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 68 KB

english, 2015

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